The ambitions of the 2030 Agenda, the Paris Agreement and other global goals have defined actionable plans and targets for the peace and prosperity of human societies and the planet. However, the effective translation of global sustainability goals and climate actions into local development policies and investment plans remains a challenge. Despite resource constraints, local and regional governments are now stepping up to adopt reforms that can put city regions on a more sustainable and climate-resilient path. In fact, mayors and local leaders are now being recognised as key decision-makers in driving progress towards global goals by stimulating local actions. Recognising the need to showcase successful strategies, share best practices and inspire innovative approaches, this session will invite local leaders (from Japan and overseas) and international experts, to provide a co-learning platform to explore diverse perspectives on synergistically achieving global goals, while also addressing local needs and concerns. Leveraging this opportunity, the session will explore the potential of implementing the Circulating and Ecological Sphere (CES) approach, which focuses on developing the SDGs at the regional and local levels and integrating the social, economic and environmental dimensions of sustainable development, under the current priority actions for maximising the vitality of city regions in the context of Asia.